Aging Healthfully

Darwin Trilogy

  Darwin Trilogy
Item: Volume 11
SKU: Volume 11
Volume 11
Price: $95.00

Weight: 3.000 lbs.

This product cannot be shipped outside the USA.

From the Preface to Volume 11 by Majid Ali, M.D.

In 2003, I recognized the need for a new principle of integration for clinical medicine. This principle accepts all established scientific facts of human biology and holds that none of them be used alone in making clinical care decisions. I designated that principle as the Darwin Principle and proposed that it be held higher than all others in clinical medicine.1 The Darwin Principle incorporates all new scientific observations in the integrative whole and asserts that none of them can singly be accepted as the definitive evidence to support any choice of treatment. All new information must be seen through the prism of the existing body of knowledge. The core tenet of the Darwin Principle is: No part can be understood except through an understanding of its relationships with the whole.

    When I reflect on the matters of health and disease, my mind often drifts to the stories of the three Furies of Greek mythology. The ancient Greeks had three evil goddesses: Tisiphone, Megaera, and Alecto. Each evil goddess was assigned the task of spreading a different evil: Tisiphone engages in torture and murder; Megaera is full of malice and causes jealousy in her victims; and Alecto fumes with anger, forever inciting and perpetuating anger in others.

    In past writings, I have recognized three micro-furies of personal health: excess acidity (acidosis), incremental free radical activity (oxidosis), and clotting-unclotting dysequilibrium.* The furies fan each other's fury, and together cause  dysfunctional oxygen (dysox).2 In the context of human biology, I have recognized three global macro-furies of toxic thoughts, toxic environment, and toxic foods.3

The Dysox Model

    There is but one fundamental difference between a healthy cell and an unwell cell: a healthy cell has well preserved oxygen homeostasis and  utilizes oxygen, without building incremental oxidative stress (oxidosis) and without accumulating organic acids (acidosis). In contrast, an unwell cell cannot utilize oxygen adequately, retains excess acids, and generates increased oxyradical activity. I have designated this state as dysoxygenosis (dysox, for short).4-7 For patient education, I use the term dysfunctional oxygen metabolism.6-7 This state is created by the cumulative consequences of each and every factor that interrupts or impedes mitochondrial electron transfer and related events of cellular energetics—much like an automobile engine which clogs rapidly when it cannot burn fuel completely. In the dysox state, blockages at different levels of the Krebs cycle are seen, and the metabolism of sugars, fats, and proteins is impaired. The existence of the cellular dysox state in a given patient can be established expediently by measuring, in a morning urine sample, the excretion of  metabolic intermediates of the Krebs cycle and other metabolic pathways.8,9

    In 1831, Charles Robert Darwin (1809-1882)  started his journey aboard the British Navy ship H.M.S. Beagle around South America. Over a period of five years, he accumulated an enormous number of biologic and geologic samples, studied them intensively, reflected on their inter-connectedness, and formed his simple—yet comprehensive—theory of natural selection. In 1850, he published On the Origin of Species which, in my view, is the most significant work in biologic sciences. Darwin's core tenet is, indeed, the Darwin Principle: No part can be understood except through an understanding of its relationships with the whole. 

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